Patent · US Active

Induced pacemaker and Purkinje cells from adult stem cells

US9913865B2 · kind B2 · utility

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13Claims

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Assignees

INGENERON, INC. · US
ALLIANCE OF CARDIOVASCULAR RESEARCHERS · US

Inventors

Eckhard Alt · Ottobrunn, DE
Tahereh KARIMI · Houston, US

Key dates

Filing date	Dec 28, 2015
Grant date	Mar 13, 2018
Priority date	—
Expiry date	Dec 28, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2510/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.