Carrier-linked prostanoid prodrugs

US9913912B2 · kind B2 · utility

Assignee

• ASCENDIS PHARMA A/S · DK

Inventors

• Harald Rau · Würzburg, DE
• Guillaume Maitro · Mannheim, DE
• Ulrich Hersel · Heidelberg, DE
• Oliver Keil · Glienicke, DE
• Thomas Wegge · Heidelberg, DE

Key dates

• Filing date: Dec 6, 2013
• Grant date: Mar 13, 2018
• Expiry date: Dec 6, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to carrier-linked prostanoid prodrugs of formula (I) Z1—(X0-L0-PG0)y (I), wherein Z1, X0, L0, PG0 and y have the meaning as indicated in the description and claims; pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising the same. It further relates to their use as medicaments, especially for treating, controlling, delaying or preventing pulmonary arterial hypertension.