Stearoyl amino acid salt and preparation method and application thereof

US9914698B2 · kind B2 · utility

Assignee

• SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE · CN

Inventors

• Yang Lu · Hefei, CN
• Jianhua Liu · Orlando, US
• Shuangqi TANG · Shanghai, CN
• Hongzhuan Chen · Shanghai, CN

Key dates

• Filing date: Nov 5, 2014
• Grant date: Mar 13, 2018
• Expiry date: Nov 5, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C231/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A stearoyl amino acid salt having a structural formula of the general formula (I), wherein R1 is H or an aromatic base capable of being substituted by one or more substituents, or a C1-4 straight chain or an alkyl with a branched chain, the substituent being an alcoholic hydroxyl group or a phenolic hydroxyl group; and R2 is a C11-25 saturated or unsaturated aliphatic group. Also provided are methods of preparing the stearoyl amino acid salt, and methods of using the stearoyl amino acid salt. Compared to a prototype drug stearoyl amino acid, the stearoyl amino acid salt described herein has excellent physicochemical properties, good stability, high relative bioavailability, a strong drug effect and a high safety factor. It is thus expected to become a candidate for clinical treatment of neurodegenerative diseases and acute brain injury, and a clinical drug for weight loss, thus having broad application prospects.