C-aryl glycosid derivatives, pharmaceutical composition, preparation process and uses thereof

US9914724B2 · kind B2 · utility

Assignee

• SHANGHAI DE NOVO PHARMATECH CO., LTD. · CN

Inventors

• Daxin Gao · Houston, US
• Heping Yang · Shanghai, CN
• Pei-Ning WANG · Shanghai, CN

Key dates

• Filing date: Apr 1, 2015
• Grant date: Mar 13, 2018
• Expiry date: Apr 1, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to a kind of C- aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts withvia Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts withvia nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C- aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention relates to a kind of C- aryl glycoside derivatives, it's pharmaceutically acceptable salts or compositions thereof for preparing a SGLT inhibitor. The C- aryl glycoside derivatives of this invention provides a new direction for SGLT inhibitors.