Cross-reactive Staphylococcus aureus antibody

US9914767B2 · kind B2 · utility

Assignee

• ARSANIS Biosciences GmbH · AT

Inventors

• Eszter Nagy · Wien, AT
• Adriana BADARAU · Wien, AT
• Harald ROUHA · Wien, AT
• Lukas Stulik · Wien, AT
• Gabor Nagy · Redmond, US
• Irina MIRKINA · Wien, AT
• Zoltán Magyarics · Wien, AT
• Zehra Visram · Wien, AT
• Michaela Jaegerhofer · Wien, AT
• Manuel Zerbs · Wien, AT
• Ivana Dolezilkova · Wien, AT
• Astrid Teubenbacher · Wien, AT
• Michael BATTLES · Canaan, US
• Bianka Prinz · Lebanon, US

Key dates

• Filing date: Apr 17, 2013
• Grant date: Mar 13, 2018
• Expiry date: Apr 17, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The subject relates to a cross-neutralizing antibody comprising at least one polyspecific binding site that binds to alpha-toxin (Hla) and at least one of the bi-component toxins of Staphylococcus aureus, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated conformational epitope recognized by a specific cross-neutralizing antibody.