Nucleic acid-based linkers for detecting and measuring interactions
US9914958B2 · kind B2 · utility
8Cited by
6References
34Claims
0Family size
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Key dates
| Filing date | Nov 5, 2012 |
| Grant date | Mar 13, 2018 |
| Priority date | — |
| Expiry date | Nov 5, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5308
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first and/or a second oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.