Water soluble polyfluorene functionalized with glucuronic acid useful in bilirubin sensing
US9915669B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 31, 2014 |
| Grant date | Mar 13, 2018 |
| Priority date | — |
| Expiry date | Sep 22, 2034 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/146666
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provide water soluble polyfluorenes functionalized with glucuronic acid useful in sensing bilirubin in aqueous medium and process for preparation thereof.The invention further deals with detecting bilirubin in human serum samples in the range from normal (<25 μmol/L˜1.2 mg/dL) human bilirubin level to jaundiced bilirubin level (>50 μmol/L˜2.5 mg/dL).1 This is a fluorescence turn-off mode of detection where blue fluorescence of polymer quenches and becomes colorless. The water soluble polyfluorenes functionalized with glucuronic acid can detect free bilirubin in the range from 1×10−4 M to 1×10−7 M moles in aqueous and buffer media as a change in the fluorescence signal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.