Haplotying of HLA loci with ultra-deep shotgun sequencing
US9920370B2 · kind B2 · utility
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Key dates
| Filing date | Apr 24, 2015 |
| Grant date | Mar 20, 2018 |
| Priority date | — |
| Expiry date | Sep 30, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/172
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
Methods are provided to determine the entire genomic region of a particular HLA locus including both intron and exons. The resultant consensus sequences provides linkage information between different exons, and produces the unique sequence from each of the two genes from the individual sample being typed. The sequence information in intron regions along with the exon sequences provides an accurate HLA haplotype.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.