Process line for the production of freeze-dried particles

US9920989B2 · kind B2 · utility

Assignee

• Sanofi Pasteur SA · FR

Inventors

• Bernhard Luy · Glückstadt, DE
• Matthias Plitzko · Neuenbürg, DE
• Manfred Struschka · Auggen, DE

Key dates

• Filing date: Oct 4, 2012
• Grant date: Mar 20, 2018
• Expiry date: Oct 4, 2032

Classification

• Technology area (CPC F): Mechanical Engineering; Lighting; Heating
• CPC primary: F26B5/065
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A process line (300) for the production of freeze-dried particles under closed conditions comprising at least a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles and a bulk freeze-dryer (304) for freeze drying the particles, the freeze-dryer (304) comprising a rotary drum for receiving the particles. Further, a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304). For the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for operation preserving sterility of the product to be freeze-dried and/or containment.