Detection of translocation events using graphene-based nanopore assemblies

US9921181B2 · kind B2 · utility

Assignee

• International Business Machines Corporation · US

Inventors

• Julia Baldauf · Melbourne, AU
• Matthew Downton · Melbourne, AU
• Natalie Gunn · Melbourne, AU
• Stefan Harrer · Hampton, AU
• Sridhar Kannam · Brisbane, AU
• Christine Schieber · Melbourne, AU
• John M. Wagner · Melbourne, AU

Key dates

• Filing date: Aug 7, 2014
• Grant date: Mar 20, 2018
• Expiry date: Jul 6, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/48721
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Translocation events are sensed using composite nanopore assemblies including nanopores formed in graphene sheets. Single molecule detection and characterization and multi-molecule characterization and identification are provided using such assemblies. Multiple electrodes associated with nanofluidic sensors facilitate detection of ionic current through a nanopore as well as tunneling currents. Current signals of individual molecules are estimated from the combination of an ionic current signal through the nanopore and tunneling current signals obtained at specific locations within the nanopore.