Alkylphosphocholine analogs for multiple myeloma imaging and therapy

US9925283B2 · kind B2 · utility

Assignee

• Wisconsin Alumni Research Foundation · US

Inventors

• Jamey P. Weichert · Fitchburg, US
• Chorom Pak · Madison, US
• Benjamin Titz · Madison, US
• Fotis Asimakopoulos · Madison, US
• Roberta Marino · Cordova, US
• Mario Otto · Fitchburg, US
• Kevin Kozak · Madison, US

Key dates

• Filing date: Apr 11, 2016
• Grant date: Mar 27, 2018
• Expiry date: Apr 11, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/60
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by multiple myeloma tumor cells. The alkylphophocholine analogs are compounds having the formula:or salts thereof, wherein n is an integer from 12 to 24; and R2 is —N+H3, —N+H2X, —N+HX2, or —N+HX3, wherein each X is independently —CH3 or —C2H5. The compounds can be used to treat multiple myeloma or to detect multiple myeloma. In therapeutic treatment, R1 includes a radionuclide that locally delivers therapeutic dosages of radiation to the multiple myeloma tumors cells that preferentially take up the compound. In detection/imaging applications, R1 includes a detection moiety, such as a fluorophore or a radiolabel.