Patent · US Active

Method for preparing azetidinone compound and intermediate of azetidinone compound

US9926268B2 · kind B2 · utility

0Cited by

5References

8Claims

0Family size

Assignee

Zhejiang Hisun Pharmaceutical Co., Ltd. · CN

Inventors

Hua Bai · Lake Jackson, US
Xuyang Zhao · Sichuan, CN
Yuncai Zhang · Zhejiang, CN
Xufei Li · Taizhou City, CN
Yong Zhang · Sichuan, CN
Dezhou Xu · Taizhou City, CN
Li Zhang · New Milford, US
Xiaojie Xu · Taizhou City, CN
Qifeng Zhu · Zhejiang, CN
Xiaoming Wang · Sunnyvale, US
Zhiqing Yang · Taizhou City, CN
Zehua Zhong · Taizhou City, CN
Jian Zhang · Taizhou City, CN

Key dates

Filing date	Jun 5, 2015
Grant date	Mar 27, 2018
Priority date	—
Expiry date	Jun 5, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C69/732
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the raw material and is subjected to Grignard addition, stereoselective dehydration, ester group reduction, hydroxyl group protection, addition with imine after condensation with a chiral auxiliary, cyclization and deprotection to obtain the compound represented by formula (I). The present invention has advantages of easily available raw material, a few synthetic steps, simple operation, high yield, good stereoselectivity and low cost, and can be used for industrial production.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.