Octahydrocyclopentapyrroles, their preparation and use

US9926271B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Konstantin Petrukhin · Collegeville, US
• Christopher Cioffi · Troy, US
• Graham Johnson · Madison, US
• Nicoleta Dobri · New York, US
• Emily Freeman · Voorheesville, US
• Ping Chen · Fujian, CN
• Michael Conlon · Albany, US
• Lei Zhu · Hefei, CN

Key dates

• Filing date: Mar 13, 2017
• Grant date: Mar 27, 2018
• Expiry date: Mar 13, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatment of diseases characterized by excessive lipofuscin accumulation in the retina.