Vortioxetine intermediate and synthesis process thereof
US9926286B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Mar 25, 2015 |
| Grant date | Mar 27, 2018 |
| Priority date | — |
| Expiry date | Mar 25, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/205
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a new intermediate II and a method for synthesizing the same. The method comprises: (a) firstly diazotizing a compound of formula I as a raw material, and then halogenating to obtain an intermediate II; and (b) reacting the intermediate II with a compound III to obtain a compound IV, hydrolyzing the obtained compound IV directly without being separated to obtain Vortioxetine represented by compound V. The intermediate II can be used for synthesizing Vortioxetine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.