Processes of synthesizing dihydropyridophthalazinone derivatives

US9926303B2 · kind B2 · utility

Assignee

• Medivation Technologies LLC · US

Inventors

• Bing Wang · San Jose, US
• Daniel Chu · Santa Clara, US
• Yongbo Liu · Shanghai, CN
• Quan Jiang · New Orleans, US
• Lei Lu · Kowloon, CN

Key dates

• Filing date: Jun 2, 2014
• Grant date: Mar 27, 2018
• Expiry date: Jun 2, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided herein are processes for synthesizing dihydropyridophthalazinone derivatives, such as for example, 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one and its stereoisomers, which are potent poly(ADP-ribose)polymerase (PARP) inhibitors as well as novel synthetic intermediate compounds.