Chimeric human-llama antigens and methods of use

US9926364B2 · kind B2 · utility

Assignee

• ARGEN-X N.V. · NL

Inventors

• Johannes Joseph Wilhelmus De Haard · Vlaardingen, NL
• Natalie De Jonge · Zwijnaarde, BE
• Anna Hultberg · Sint-Martens-Latem, BE
• Christophe Blanchetot · Laarne, BE
• Karen Silence · Overijse, BE
• Peter Ulrichts · Breda, NL
• Torsten Dreier · Breda, NL

Key dates

• Filing date: Nov 5, 2012
• Grant date: Mar 27, 2018
• Expiry date: Sep 7, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/40
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are chimeric, camelid-human (e.g., llama-human) polypeptides comprising a first antigenic polypeptide portion and a second antigenic polypeptide portion wherein the first antigenic portion is a derived from a first portion of a camelid (e.g., llama) and the second antigenic portion is a human polypeptide homolog of a second portion of the camedid antigen. The chimeric polypeptides are useful inter alia for epitope mapping and generation of antibodies that bind to a desired region of human antigen.