Tyrosine kinome

US9926606B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Alberto Bardelli · Baltimore, US
• D. Williams Parsons · Bellaire, US
• Victor Velculescu · Dayton, US
• Kenneth W. Kinzler · Baltimore, US
• Bert Vogelstein · Baltimore, US

Key dates

• Filing date: Dec 7, 2015
• Grant date: Mar 27, 2018
• Expiry date: Dec 7, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in ˜20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention.