Use of gastrointestinally administered porous enteron sorbent polymers to prevent or treat radiation induced mucositis, esophagitis, enteritis, colitis, and gastrointestinal acute radiation syndrome

US9931357B2 · kind B2 · utility

Assignee

• CytoSorbents, Inc. · US

Inventors

• Humayra Begum Ali · Princeton, US
• Thomas D. Golobish · Princeton, US
• Vincent J. Capponi · Monmouth Junction, US
• Phillip P. Chan · Cherry Hill, US
• Wei-Tai Young · Fryeburg, US
• Andrew Scheirer · Bethlehem, US

Key dates

• Filing date: Oct 2, 2015
• Grant date: Apr 3, 2018
• Expiry date: Oct 2, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F22/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).