Oxyntomodulin analogs and methods of making and using same

US9931379B2 · kind B2 · utility

Assignees

• The Research Foundation for The State University of New York · US
• THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH · US

Inventors

• Qing Lin · San Diego, US
• Avinash Muppidi · Carmel, US
• Weijun Shen · San Diego, US
• Huafei Zou · San Diego, US
• Peter G. Schultz · Village of La Jolla, US
• Yulin Tian · Amherst, US

Key dates

• Filing date: Mar 7, 2017
• Grant date: Apr 3, 2018
• Expiry date: Mar 7, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are oxyntomodulin analogs. The peptide analogs have at least two cysteines. The two cysteines are separated by six amino acids such that they can be crosslinked using suitable crosslinking moieties. The crosslinked peptides have long half-lives and/or efficacy. For example, peptide analog compositions are used for inducing weight loss and/or reducing blood glucose levels.