Genetic attenuation of plasmodium by B9 gene disruption
US9931389B2 · kind B2 · utility
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Key dates
| Filing date | Mar 14, 2017 |
| Grant date | Apr 3, 2018 |
| Priority date | — |
| Expiry date | Mar 14, 2037 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are mutant Plasmodium-species parasites that are genetically attenuated (GAP). They retain the ability to infect a host and invade host hepatocytes but subsequently their development is completely arrested within the liver stage of Plasmodium development and the parasites do not reach the blood stage of development. Vaccines and pharmaceutical compositions comprising genetically attenuated Plasmodium sporozoites as well as methods of using the same are likewise provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.