Injectable silk fibroin particles and uses thereof

US9931434B2 · kind B2 · utility

Assignees

• Trustees of Tufts College · US
• University of Pittsburgh—Of the Commonwealth System of Higher Education · US
• Wake Forest University Health Sciences · US

Inventors

• Evangelia Bellas · Somerville, US
• Kacey Gribbin Marra · Weavertown, US
• J. Peter Rubin · Pittsburgh, US
• David L. Kaplan · Seattle, US
• James J. Yoo · Winston-Salem, US

Key dates

• Filing date: Nov 9, 2012
• Grant date: Apr 3, 2018
• Expiry date: Nov 9, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2982
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.