Patent · US Active

Diagnosis and treatment of chronic obstructive pulmonary disease (COPD) based on elevated levels of extracellular H3 protein

US9933435B2 · kind B2 · utility

0Cited by

0References

18Claims

0Family size

Assignee

Temple University-Of The Commonwealth System of Higher Education · US

Inventors

Salim Merali · Queens, US
Camilo Moncada · Philadelphia, US
Steven G. Kelsen · Rydal, US
Carlos A. Barrero · Philadelphia, US
Oscar Mauricio Perez Leal

Key dates

Filing date	Feb 16, 2016
Grant date	Apr 3, 2018
Priority date	—
Expiry date	Feb 16, 2036

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/56
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.