Combinatorial compositions and methods for treatment of melanoma

US9937161B2 · kind B2 · utility

Assignees

• The General Hospital Corporation · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Rizwan Haq · Boston, US
• David E. Fisher · Newton, US
• Hans Ragnar Widlund · Brookline, US

Key dates

• Filing date: Mar 6, 2014
• Grant date: Apr 10, 2018
• Expiry date: Mar 6, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments described here are combinatorial compositions and methods using these compositions for treating melanomas having activated mutations. The compositions comprises combinations of inhibitors of a MAPK pathway, ERK inhibitors, EGFR inhibitors, oxidative phosphorylation (OXPHOS) inhibitors, inhibitors of B-Raf, mitochondrial inhibitors, c-KIT inhibitors, MEK inhibitors and tigecycline or a derivative thereof.