Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase
US9937171B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Apr 10, 2015 |
| Grant date | Apr 10, 2018 |
| Priority date | — |
| Expiry date | Apr 10, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In some embodiments, the present invention relates to novel small molecule inhibitors that block the CXCR4-SDF-1 signaling pathway by directly inhibiting members of the Tec family of kinases, namely Bruton's tyrosine kinase (BTK), and their use in treating diseases in which pathogenesis is mediated by the CXCR4/SDF-1 signaling pathway.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.