Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents
US9937186B2 · kind B2 · utility
1Cited by
5References
19Claims
0Family size
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Key dates
| Filing date | Mar 10, 2015 |
| Grant date | Apr 10, 2018 |
| Priority date | — |
| Expiry date | Mar 10, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A genus of arylsulfonamide derivatives of aminocycloalkanols is disclosed. The compounds are of the following genus:The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.
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