Induction of cross-reactive cellular response against rhinovirus antigens
US9937252B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Feb 6, 2014 |
| Grant date | Apr 10, 2018 |
| Priority date | — |
| Expiry date | Feb 6, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/32734
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns: a) an isolated peptide comprising an amino acid sequence which is at least 90% identical to the VP4 amino acid sequence of a rhinovirus, or an isolated polynucleotide comprising a nucleic acid sequence encoding said peptide, placed under the control of the elements necessary for its expression in a mammalian cell; and/or b) an isolated peptide comprising an amino acid sequence of at least 100 amino acids which is at least 90% identical to an amino acid sequence located in the last 363 C-terminal amino acids of the RNA polymerase of a rhinovirus, or an isolated polynucleotide comprising a nucleic acid sequence encoding said peptide, placed under the control of the elements necessary for its expression in a mammalian cell; and c) a Th1 adjuvant when said immunogenic composition comprises one or more of said isolated peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.