Compounds for affinity chromatography and for extending the half-life of a therapeutic agent
US9938243B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Sep 7, 2017 |
| Grant date | Apr 10, 2018 |
| Priority date | — |
| Expiry date | Sep 7, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.