Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof

US9938258B2 · kind B2 · utility

Assignee

• Karyopharm Therapeutics Inc. · US

Inventors

• Erkan Baloglu · Stoneham, US
• Sharon Shechter · Andover, US
• Sharon Shacham · Gdera, IL
• Dilara McCauley · Cambridge, US
• William Senapedis · Millis, US
• Gali Golan · Shoeva, IL
• Ori Kalid · Rehovot, IL

Key dates

• Filing date: Nov 27, 2013
• Grant date: Apr 10, 2018
• Expiry date: Nov 27, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I:or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.