Compounds and methods for kinase modulation, and indications therefor

US9938273B2 · kind B2 · utility

Assignee

• Plexxikon Inc. · US

Inventors

• Guoxian Wu · Palo Alto, US
• Jeffrey Wu · San Francisco, US
• Katrina Chan · Fremont, US
• Ken Dong · Berkeley, US
• Todd Ewing · San Diego, US
• Prabha N. Ibrahim · Mountain View, US
• Jack Lin · Hercules, US
• Wayne Spevak · Berkeley, US
• Ying Zhang · Beijing, CN

Key dates

• Filing date: Dec 6, 2016
• Grant date: Apr 10, 2018
• Expiry date: Dec 6, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/107
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula I:or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Z2, Z3, and Z5 are as described herein, compositions thereof, and uses thereof.