Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors

US9938300B2 · kind B2 · utility

Assignee

• FORMA Therapeutics, Inc. · US

Inventors

• Stephanos Ioannidis · Natick, US
• Adam Charles Talbot · Guilford, US
• Bruce Follows · Littleton, US
• Alexandre Joseph Buckmelter · Superior, US
• Minghua Wang · Acton, US
• Ann-Marie Campbell · Monroe, US

Key dates

• Filing date: Feb 4, 2016
• Grant date: Apr 10, 2018
• Expiry date: Feb 4, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.