Patent · US Active

Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase

US9938323B2 · kind B2 · utility

8Cited by

0References

23Claims

0Family size

Assignee

Novartis AG · CH

Inventors

Jan Grunewald · San Diego, US
Yunho Jin · San Diego, US
Weijia Ou · San Diego, US
Tetsuo Uno · San Diego, US

Key dates

Filing date	Nov 5, 2015
Grant date	Apr 10, 2018
Priority date	—
Expiry date	Nov 5, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (I), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.