Tumor necrosis factor (TNF) superfamily receptor IgM antibodies and uses thereof

US9938347B2 · kind B2 · utility

Assignee

• IGM BIOSCIENCES A/S · DK

Inventors

• Beatrice Tien-Yi Wang · Mountain View, US
• Max Allen Schwarzer · Los Altos, US
• Bruce Keyt · Pacifica, US
• Ramesh Baliga · Redwood City, US

Key dates

• Filing date: Jun 30, 2017
• Grant date: Apr 10, 2018
• Expiry date: Jun 30, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/75
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

This disclosure provides dimeric, pentameric, and hexameric Tumor Necrosis Factor (TNF) superfamily receptor protein binding molecules and methods of using such binding molecules to direct apoptosis-mediated killing of TNF receptor-expressing cells.