Compositions, methods and uses for alpha-1 antitrypsin fusion molecules

US9938353B2 · kind B2 · utility

Assignee

• The Regents of the University of Colorado, a Body Corporate · US

Inventors

• Charles A. Dinarello · Boulder, US
• James D. Crapo · Englewood, US
• Soohyun Kim · Daejeon, KR

Key dates

• Filing date: Jun 22, 2012
• Grant date: Apr 10, 2018
• Expiry date: May 13, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments herein report compositions of alpha-1 antitrypsin fusion polypeptides or peptide derivatives thereof. In certain embodiments, compositions and methods relate to generating a construct of use in pharmaceutically acceptable compositions to treat a subject in need of alpha-1 antitrypsin therapy or treatment. In other embodiments, compositions and methods disclosed herein concern linking alpha-1 antitrypsin or derivative thereof to an immune fragment.