Method for the preparation of macroporous particles and macroporous microclusters
US9938390B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 22, 2013 |
| Grant date | Apr 10, 2018 |
| Priority date | — |
| Expiry date | Nov 22, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08J2333/06
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method for producing macro porous micro-clusters is proposed comprising at least the following individual steps in given order: a) synthesis of dispersed cross-linked polymeric latex primary particles starting from at least one monomer or oligomer using emulsion polymerization; b) swelling of the primary particles with a liquid comprising at least an additional charge of monomer and/or oligomer and a cross-linker, optionally further comprising functionalization agents; c) destabilization by increase of ionic strength (by adding a salt and/or acid and/or base) in a combination with application of shear, both being above the gel formation boundary of the phase diagram, until agglomerates composed of primary particles of the desired size are formed; d) polymerization of the agglomerates to form the macro porous micro-clusters. Furthermore the invention to relates to correspondingly produced micro-clusters and uses of such micro-clusters in particular for chromatographic purposes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.