Patent · US Active

Multiplex isolation of protein-associated nucleic acids

US9938524B2 · kind B2 · utility

3Cited by

1References

24Claims

0Family size

Assignee

ACTIVE MOTIF, INC. · US

Inventors

Joseph Fernandez · Carlsbad, US
Mary Anne Jelinek · Carlsbad, US
Brian Stanley Egan · Redding, US

Key dates

Filing date	Nov 23, 2012
Grant date	Apr 10, 2018
Priority date	—
Expiry date	Nov 23, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/6804
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention provides novel methods and materials for genetic and genomic analysis using single or multiplex isolation of protein-associated nucleic acids, including transposase-assisted chromatin immunoprecipitation (TAM-ChIP) and antibody-oligonucleotide proximity ligation. These methods comprise tagging and isolating chromatin or other protein-associated nucleic acids and using antibody-oligonucleotide complexes that recognize the proteins associated with such nucleic acids.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.