Molecules inhibiting the human immunodeficiency virus type 1 (HIV-1), method for the production thereof and applications of same
US9938532B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 22, 2013 |
| Grant date | Apr 10, 2018 |
| Priority date | — |
| Expiry date | Nov 22, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2469/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to an aptamer, the structure thereof comprising at least one nucleotide sequence 5′-GGCA(A/G)GGA-3′, that can specifically bind to the poly(A) hairpin of the 5′UTR region of the genome of the human immunodeficiency virus type 1 (HIV-1), providing the method for producing aptamers with said sequence by means of a combination of experimental techniques of in vitro selection of nucleic acids with computational techniques of sequence optimization. The invention also relates to a DNA gene structure for synthesizing said aptamers, preferably RNA. The invention further relates to the different uses of the above-mentioned aptamer, including the use thereof as a biosensor molecule for detecting and/or quantifying HIV-1, as an inhibitor of the production of viral particles of HIV-1, and to the application thereof in medicine, the invention also relating to a method for treating a disease caused by HIV-1, and to a pharmaceutical composition comprising said aptamer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.