Compositions and methods for aptamer screening

US9939443B2 · kind B2 · utility

Assignee

• Caris Life Sciences Switzerland Holdings GMBH · CH

Inventors

• David Spetzler · Scottsdale, US
• Valeriy Domenyuk · Phoenix, US
• Tassilo Hornung · Phoenix, US
• Gunter Mayer · Untereisesheim, DE
• Michael Famulok · Bonn, DE

Key dates

• Filing date: Dec 19, 2013
• Grant date: Apr 10, 2018
• Expiry date: Jul 29, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/5308
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods are provided for selecting aptamers that are specific to a target of interest from amongst a library of potential aptamer sequences. Aptamers disclosed can be used to detect and/or characterize biological entities of interest, e.g. microvesicles and/or surface antigens. Further disclosed are biomarkers that can be used for diagnosing different disorders including different types of cancer.