Proline-rich peptides protective against S. pneumoniae
US9943583B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Dec 2, 2014 |
| Grant date | Apr 17, 2018 |
| Priority date | — |
| Expiry date | Dec 2, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/73
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.