Patent · US Active

Reversible gene expression

US9943611B2 · kind B2 · utility

3Cited by

3References

25Claims

0Family size

Assignee

CALIFORNIA INSTITUTE OF TECHNOLOGY · US

Inventors

Alejandro Benjamin Balazs · Berkeley, US
David Baltimore · Pasadena, US

Key dates

Filing date	Oct 30, 2013
Grant date	Apr 17, 2018
Priority date	—
Expiry date	Sep 30, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2840/44
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

According to some embodiments herein, expression systems and methods for reversible gene expression are provided. In some embodiments, adeno-associated viral vectors encoding a gene product of interest and comprising a plurality of recombinase target sites are provided. In some embodiments, a source of recombinase is provided. In some embodiments, the gene product of interest is expressed, and the recombinase then induces recombination events between the recombinase target sites, thus reducing or eliminating expression of the gene product of interest.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.