Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

US9944592B2 · kind B2 · utility

Assignee

• XENOPORT, INC. · US

Inventors

• Mark A. Gallop · Santa Clara, US
• Fenmei Yao · Mountain View, US
• Maria J. Ludwikow · Cupertino, US
• Thu Phan · Fremont, US
• Ge Peng · Mountain View, US

Key dates

• Filing date: Dec 22, 2016
• Grant date: Apr 17, 2018
• Expiry date: Dec 22, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.