Indoles as respiratory syncytial virus antiviral agents

US9944638B2 · kind B2 · utility

Assignee

• Janssen Sciences Ireland UC · IE

Inventors

• Ludwig Paul Cooymans · Beerse, BE
• Samuël Dominique Demin · Ekeren, BE
• Lili Hu · Mechelen, BE
• Tim Hugo Maria Jonckers · Heist-op-den-Berg, BE
• Pierre Jean-Marie Bernard Raboisson · Sligo, IE
• Abdellah Tahri · Anderlecht, BE
• Sandrine Marie Helene Vendeville · Woluwe-Saint-Pierre - Sint-Pieters-Woluwe, BE

Key dates

• Filing date: Apr 22, 2016
• Grant date: Apr 17, 2018
• Expiry date: Jun 10, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Indoles having inhibitory activity on RSV replication and having the formula Ithe prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.