Patent · US Active

Boron-containing diacylhydrazine compounds

US9944659B2 · kind B2 · utility

0Cited by

70References

19Claims

0Family size

Assignee

INTREXON CORPORATION · US

Inventors

Ray Anthony James · Bristol, US
Sheela K. Chellappan · Clarksburg, US
Robert Eugene Hormann · Melrose Park, US

Key dates

Filing date	Sep 16, 2015
Grant date	Apr 17, 2018
Priority date	—
Expiry date	Nov 27, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D263/06
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present disclosure provides boron-containing diacylhydrazines having Formula I:and the pharmaceutically acceptable salts and solvates thereof, wherein A, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.