Patent · US Active

Chelator and use thereof

US9944722B2 · kind B2 · utility

0Cited by

0References

9Claims

0Family size

Assignee

GE Healthcare BioProcess R&D AB · SE

Inventors

Mattias Algotsson · Uppsala, SE
Lars Andersson · Uppsala, SE
Eggert Brekkan · Uppsala, SE
Lee Hedemyr · Uppsala, SE
Jean-Luc Maloisel · Uppsala, SE
Ronnie Palmgren · Uppsala, SE

Key dates

Filing date	May 30, 2011
Grant date	Apr 17, 2018
Priority date	—
Expiry date	Aug 1, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C323/60
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two adjacent immobilized metal ions simultaneously to a histidine-tagged biomolecule, which gives advantageous properties regarding strength of binding compared to a corresponding monomer chelator. In addition, a dimer increases the selectivity (ease of separation) against non-tagged biomolecules with low metal-ion affinity.The dimeric pentadentate chelator according to the invention has the following general formula:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.