Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control
US9944922B2 · kind B2 · utility
8Cited by
34References
29Claims
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Key dates
| Filing date | Dec 8, 2015 |
| Grant date | Apr 17, 2018 |
| Priority date | — |
| Expiry date | Aug 4, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N1/405
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.