Methods and compositions for reducing immunosupression by tumor cells

US9944931B2 · kind B2 · utility

Assignees

• DANA-FARBER CANCER INSTITUTE, INC. · US
• The General Hospital Corporation · US

Inventors

• Kai W. Wucherpfennig · Brookline, US
• Glenn Dranoff · Lexington, US
• Penghui Zhou · Quincy, US
• Donald Shaffer · Boston, US
• Nir Hacohen · Cambridge, US
• Harvey Cantor · Boston, US
• Diana Alvarez Arias · Midland, US

Key dates

• Filing date: Jun 10, 2014
• Grant date: Apr 17, 2018
• Expiry date: Jun 10, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/178
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof.