Apparatus and method for introducing sample into a separation unit of a chromatography system without disrupting a mobile phase
US9945762B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 30, 2014 |
| Grant date | Apr 17, 2018 |
| Priority date | — |
| Expiry date | Feb 15, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/342
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and a system for introducing a sample into a mobile phase of a chromatography system is provided. The method includes initially directing the mobile phase directly into a separation unit of the chromatography system, bypassing a sample loop, the mobile phase including a combined solvent, metered from a pressurized first solvent and a second solvent; loading the sample into the sample loop, while the mobile phase continues to be directed directly into the separation unit; pressurizing the sample in the sample loop with the pressurized first solvent, while the mobile phase continues to be directed directly into the separation unit; and switching the sample loop into the mobile phase, thereby introducing the pressurized sample to the separation unit.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.