Extracellular mitochondrial components for detecting inflammatory reactions and conditions
US9945853B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 10, 2014 |
| Grant date | Apr 17, 2018 |
| Priority date | — |
| Expiry date | Oct 10, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7095
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure highlights the relationship between extracellular mitochondrial components, optionally in combination with the secreted phospholipase A2-IIA and/or an auto-antibody, and in vivo as well as in vitro and inflammatory reactions/conditions, especially those released as a result of the degradation of a platelet. The present disclosure provides methods for determining the presence of inflammatory mediators, for limiting inflammatory reactions/conditions, for the diagnosis inflammatory reactions/conditions, for screening therapeutics for the treatment and/or the alleviation of symptoms of inflammatory reactions/conditions based on the detection or modulation of the level of these extracellular mitochondrial components.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.