Methods for predicting the survival time of a patient suffering from a solid cancer based on density of B cells

US9945861B2 · kind B2 · utility

Assignees

• INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) · FR
• UNIVERSITE DE PARIS DESCARTES · FR
• ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS (APHP) · FR

Inventors

• Jerome Galon · Paris, FR
• Franck Pages · Paris, FR
• Bernhard Mlecnik · Paris, FR
• Gabriela Bindea · Paris, FR
• Herve Fridman · Paris, FR

Key dates

• Filing date: Jan 21, 2013
• Grant date: Apr 17, 2018
• Expiry date: Jan 21, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to a method for predicting the survival time of a patient suffering from a solid cancer comprising the steps consisting of i) determining the density of B cells at the invasive margin of the tumor (im) in a tumor tissue sample obtained from said patient, ii) comparing said density with a predetermined reference value and iii) providing a good prognosis when the density of B cells at the invasive margin of the tumor is higher than the predetermined reference value and a poor prognosis when the density of B cells at the invasive margin of the tumor is lower than the predetermined reference value.