Method for preparing multilayer lamellar liquid crystal emulsion including intercellular lipids
US9949900B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 27, 2013 |
| Grant date | Apr 24, 2018 |
| Priority date | — |
| Expiry date | Jul 14, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for preparing a liquid crystal emulsion includes: a) mixing, warming and dissolving intercellular lipid ingredients, non-polyoxyethylene (POE) based non-ionic surfactant, higher fatty alcohol, oil and wax to provide an oil phase part; b) mixing, warming and dissolving water, polyol and the other aqueous phase ingredients to provide an aqueous phase part; c) adding the oil phase part to the aqueous phase part, followed by agitation; d) introducing a viscosity modifier to the mixture solution under agitation; e) subjecting the mixture solution to rapid cooling under vacuum while carrying out debubbling under vacuum; and f) filtering the mixture solution through a filtering paper or filtering cloth. Provided is a stable liquid crystal emulsion having a multilayer lamellar structure including a large amount of intercellular lipid ingredients through a process using rapid cooling. The liquid crystal emulsion has an oil phase part and an aqueous phase part.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.