Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use

US9950005B2 · kind B2 · utility

Assignee

• Warsaw Orthopedic, Inc.

Inventors

• Josee Roy · Memphis, US
• William F. McKay · Memphis, US
• Jeffrey C. Marx · Germantown, US

Key dates

• Filing date: Jan 30, 2015
• Grant date: Apr 24, 2018
• Expiry date: Mar 8, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.